Fungus of the foot and nails is a lot of trouble. It is difficult to cure to the end, and the main reason is that many initially incorrectly approach this task, buying ineffective obsolete drugs or trying to be treated with folk remedies. Meanwhile, the modern pharmaceutical industry produces drugs that can quickly and dramatically relieve mycosis. One of them is Exifin. Antimycotic is available in the form of tablets and cream. But before you start using it, you need to read the instructions.
Description of the drug
Exifin is an effective medication for fungus based on terbinafine hydrochloride. Produced by a large Indian pharmaceutical company Dr. Reddy`s Laboratories Ltd.
Depending on the diagnosis and stage of the disease, the doctor may prescribe the drug in the form of:
- tablets (white, round, biconvex);
- cream (homogeneous white emulsion).
Exifin tablets containing 250 mg of active ingredient are intended for oral administration. They are sold in cartons of 16 pcs. (4 blisters for 4 pieces). The cost of one pack varies around 750-850 rubles.
The cream involves external use. Used alone or in combination with tablets (as directed by a doctor). The cost of one tube is approximately 220-250 rubles.
Information on the active substance
Terbinafine, which is part of Exifin, is a fungicidal substance from the group of allylamines with a wide spectrum of activity. It inhibits development and growth:
- dermatophytes (trichophytons, microsporum, epidermophytons);
- mold fungi (aspergillus, cladosporium, etc.);
- yeast pathogens (candida albicans);
- dimorphic fungi (pathogens of histoplasmosis, coccidoidosis).
Thus, terbinafine treats many fungal infections, and most importantly – all the most common of them:
- mycoses affecting the hairline (ringworm);
- fungal infections of smooth skin of a complicated course requiring tablets;
- mycoses of nails and skin on the legs and arms;
- candidiasis of the mucous membranes of the oral cavity, genitals, rectum, large and small skin folds.
This substance has a detrimental effect on the membrane of the fungal cell, disrupting its formation by suppressing the enzyme squalene epoxidase. This leads to the accumulation of a toxic substance – squalene, which leads to the death of the pathogen.
Terbinafine also disrupts the synthesis of ergosterol – a fat-like substance that forms the basis of the membrane. As a result, new cells cease to form, while existing cells quickly lose their viability due to changes in the permeability of the membrane.
Taken internally, terbinafine accumulates in the skin, nails, hair, subcutaneous tissue, and the secretion of the sebaceous glands. Thanks to this, the drug is always in the tissues in the desired therapeutic concentration and acts continuously. After drug withdrawal, he continues to suppress fungi for about a month due to the cumulative effect.
Indications and contraindications for taking tablets
It is advisable to take Exifin orally when local treatment alone cannot be dispensed with. The main indications for taking tablets:
- ringworm caused by trichophytons, microsporum;
- widespread and deep lesions of the skin and mucous membranes with dermatophytes, candidias;
- nail fungus (onychomycosis).
Fungal lesions of the nail plates respond very poorly to external treatment. The latter help only at the very beginning of the development of the disease. At the advanced stage, before using terbinafine in tablets and in the form of a cream, it is recommended to remove all damaged parts of the plate mechanically or chemically.
The tablet form of Exifin is classified as hepatotoxic. Therefore, a prerequisite for its use in fungal therapy is the appointment of a doctor and constant monitoring of blood counts, liver function, etc. With an increase in liver test values, the drug should be stopped immediately. After treatment with tablets, it is recommended to drink a course of hepatoprotectors.
Do not take this medicine for children under two years of age (weighing up to 20 kg), pregnant and lactating women (unless the disease threatens the life of the expectant mother or child). It is forbidden to take Exifin for people with chronic renal failure (CC less than 50 ml / min) and liver diseases.
Indications and contraindications for the use of cream
Exifin cream is used to treat local mycoses of the skin and mucous membranes:
- candidal diaper rash in children and adults;
- inguinal epidermophytosis;
- interdigital erosion on the legs and arms;
- multi-colored (pityriasis) lichen;
- different forms of foot fungus.
In addition, Exifin can be used to prevent infection with pathogenic microflora when visiting pools, saunas, public locker rooms or if a person with a fungus lives in the house.
Since the cream applied externally is practically not absorbed into the blood, it has much less contraindications than tablets. The main ban on its use is hypersensitivity to terbinafine or auxiliary components of the drug.
Pregnant exifin cream is usually not prescribed for fungus. The use of a local drug in a short course is possible only if its potential benefit to the mother outweighs the risks to the fetus.
During the lactation period, the cream can be used if prescribed by a doctor. However, nursing women should be careful that there is no contact of the baby with the treated skin. In particular, the product should not be applied to the mammary glands, hands or neck.
For children under 14 years of age, the drug is prescribed under the supervision of a pediatrician.
In general, tablets are well tolerated by patients, but sometimes they experience the following adverse reactions:
- dyspepsia (nausea, vomiting, abdominal discomfort);
- taste disturbances;
- muscle pain, joint pain;
- fatigue, depression;
- allergic skin reactions.
These phenomena require a mandatory consultation with a doctor.
The system manual does not describe systemic side effects. But the manufacturer warns that reactions from the skin are possible – burning, redness, rash. These phenomena indicate individual intolerance to the drug.
Instructions for use of Exifin in the fungus of the feet and nails
During therapy, it is important to strictly follow the recommendations of doctors and to complete the course of treatment. Otherwise, fungal colonies resistant to terbinafine will appear, followed by a relapse of the disease, which will be very difficult to cope with.
How to take pills
The duration of therapy and the regimen is prescribed by a doctor. The usual treatment regimen for toenail fungus involves a 6 or 16-week course. Such a spread occurs due to different localization and degree of damage.
For cutaneous fungus, the following recommendations:
- foot fungus (between the fingers or the type of "moccasin") is treated for 2-6 weeks;
- extensive skin lesions require a 30-day course of treatment;
- common cutaneous candidiasis, affecting the interdigital space, pass within 14-30 days.
In this case, the administration of tablets is combined with the use of external agents (creams, ointments, solutions).
For any disease, adults drink 1 tablet daily, children (weighing up to 40 kg) – half.
Often, onychomycosis is treated according to another scheme – pulse therapy. This approach was developed by Japanese scientists who proved that intermittent medication is better tolerated by patients. The dose of the active component decreases, but its degree of effectiveness is not.
If a pulse therapy is prescribed by a doctor, then Exifin is taken two tablets a day for a week. This is followed by a three-week break. The course is repeated as many times as necessary.
How to use cream
Before applying Exifin cream, the skin is washed with soap and dried (soaked) with a towel. Then a small amount of the product lubricates the desired area, gently rubbing. If the skin has erosion, diaper rash, they can be covered with a dry gauze bandage.
The duration and frequency of application of the cream depends on the causative agent of the disease:
- dermatomycosis – once a day for a week;
- candidiasis – once a day for 10-14 days;
- pityriasis versicolor – 1-2 times a day for 14 days;
- inguinal epidermophytosis – once or twice with a break of 7 days.
Cream for nail fungus is often not used.
In pharmacies, you can find many drugs with terbinafine from different manufacturers. The most famous for customers is Lamisil. This is a fairly expensive Swiss drug. Its significant advantages include many convenient forms for use:
- cream – 550 rubles;
- gel – 550 rubles;
- spray – 75 rubles;
- lotion – 850 rubles;
- tablets – 1600 for 14 pieces.
If this brand is not affordable, it will find substitutes that are more affordable at a cost:
- Terbinafine-MFF ointment (Moscow Pharmaceutical Company, Russia) – 80 rubles;
- Terbinafine-MFF tablets – 130 rubles for 10 pieces;
- Terbix cream (Altayvitaminy, Russia) – 150 rubles;
- Fungoterbin cream (Nizhpharm, Russia) – 300 rubles;
- Terbinafine tablets (Medisorb, Russia) – 430 rubles for 28 pieces.
Personal reviews about treatment with Exifin
Marina, 33 years old.
Exifin is a good drug, I have known him for a long time. My husband had a fungus on his nails, barely forced to go to the doctor. It was morally prepared that the treatment would be difficult, that you would have to drink a lot, smear, etc. But persuading a man to do all this is not easy. But everything turned out to be very simple – you swallow a pill once a day and that’s it! The fungus was completely removed.
Larisa, 40 years old.
From the fungus between the fingers has been treated many times. Immunity is weak, so every spring, when changing shoes, an exacerbation begins. It is possible to remove it only with two ointments – Kandibene and Exifin. Both are good, so I alternate them so that the body does not get used to it.